MicroRNA-122 in patients with hepatitis B and hepatitis B virus-associated hepatocellular carcinoma

Mahmoudian-Sani, Mohammad Reza and Asgharzade, Samira and Alghasi, Arash and Saeedi-Boroujeni, Ali and Adnani Sadati, Seyed Jafar and Moradi, Mohammad Taghi (2019) MicroRNA-122 in patients with hepatitis B and hepatitis B virus-associated hepatocellular carcinoma. JOURNAL OF GASTROINTESTINAL ONCOLOGY.

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Abstract

Hepatitis B virus (HBV) infection is known as a serious problem in the domain of public health and approximately 350 million people across the world are affected with this infectious disease. As well, microRNAs are recognized as a type of small non-coding RNAs that can be widely used as a diagnostic biomarker and prognosis method of special diseases. In this respect, microRNA-122 or miR-122 can play a significant role in the pathogenesis of several hepatic diseases. Given the importance of microRNA-122 in the liver as well as its pathology, this study focused on the potential functions of microRNA-122 in pathogenesis, diagnosis, and treatment of HBV infection. In this regard, the findings of previous studies had indicated that expression of microRNA-122 in patients with HBV infection could be significantly deregulated. The results of this study were consistent with the idea that diagnosis and treatment of this infectious disease using microRNA-122 could be an efficient method. Keywords Author Keywords:Hepatitis B virus (HBV); microRNA-122; hepatocellular carcinoma (HCC); biomarker KeyWords Plus:REGION CONFERS RISK; MIRNA-122-BINDING SITE; CIRCULATING MICRORNAS; REGULATORY CIRCUITRY; CELL-PROLIFERATION; VIRAL REPLICATION; DOWN-REGULATION; LIVER-CANCER; MIR-122; EXPRESSION

Item Type: Article
Subjects: QZ pathology-Neoplasms
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: marzieye nazari .
Date Deposited: 03 Nov 2019 09:30
Last Modified: 03 Nov 2019 09:30
URI: http://eprints.skums.ac.ir/id/eprint/7992

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