Serum levels of IL-32 in patients with type 2 diabetes mellitus and its relationship with TNF-α and IL-6

Fadaei, Reza and Bagheri, Nader and Heidarian, Esfandiar and Nouri, Ali and Hesari, Zahra and Moradi, Nariman and Ahmadi, Alireza and Ahmadi, Reza (2020) Serum levels of IL-32 in patients with type 2 diabetes mellitus and its relationship with TNF-α and IL-6. Cytokine. ISSN 1043-4666

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Abstract

Type 2 diabetes mellitus (T2DM) is an important public health worldwide. The main underlying mechanism of T2DM is insulin resistance which is associated with chronic inflammation. Interleukin-32 (IL-32) is a pro-inflammatory cytokine which has been implicated in pro-inflammatory responses of several human diseases. Previous studies have reported higher levels of IL-32 in inflammatory disease and obesity. The present study aimed to evaluate the serum concentrations of IL-32 in patients with T2DM and its association with cardio-metabolic parameters. This study was undertaken on 93 patients with TDM and 74 healthy controls. T2DM was diagnosed based on ADA criteria. Serum levels of IL-32, adiponectin, TNF-α, and IL-6 were measured by ELISA technique. Our findings revealed independent elevated levels of IL-32 in T2DM group (1061 (841.9–1601) pg/mL) compared to the control (630.4 (331.1–830.9) pg/mL). Furthermore, it was associated with increased risk of T2DM incidence. IL-32 indicated a positive correlation with body mass index, fasting blood glucose, TNF-α, and IL-6 in patients with T2DM. Furthermore, linear regression showed independent association between IL-32 and IL-6 plus TNF-α in patients’ group. The results of the present study revealed higher levels of IL-32 in T2DM patients which have been associated with inflammatory markers. These results suggest the possible role of IL-32 in chronic inflammation in patients with

Item Type: Article
Subjects: QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: marzieye nazari .
Date Deposited: 29 Sep 2019 05:07
Last Modified: 29 Sep 2019 05:07
URI: http://eprints.skums.ac.ir/id/eprint/7974

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