The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus.

Bahmani, Mahmoud and Taherikalani, Morovat and Khaksarian, Mojtaba and Rafieian-Kopaei, Mahmoud and Ashrafi, Behnam and Nazer, Mohammadreza and Soroush, Setareh and Abbasi, Naser and Rashidipour, Marzieh (2019) The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus. Future Science OA. ISSN 2056-5623

[img]
Preview
Text
fsoa-05-371.pdf - Published Version

Download (1MB) | Preview

Abstract

AIM: This study was designed to evaluate the synergistic activities of hydroalcoholic extracts of medicinal plants Origanum vulgare and Hypericum perforatum and their active components, carvacrol and hypericin against Staphylococcus aureus. METHODS: The synergistic effects of the plants, as well as carvacrol and hypericin, were examined using a checkered method against S. aureus (ATCC 12600). RESULTS: A fractional inhibitory concentration of 0.5 was obtained for combination of O. vulgare and H. perforatum and 0.49 for combination of the active ingredients carvacrol and hypericin, both of which indicated a synergistic effect. CONCLUSION: This preliminary evaluation demonstrated a synergistic property of O. vulgare and H. perforatum extracts in treating S. aureus infection. This study indicates that combination of the plants, as well as combination of carvacrol and hypericin, might be used as a new antibacterial strategy against S. aureus. KEYWORDS: Gram positive; Staphylococcus aureus; antibacterial; antibiotic; checkered carried out to Fratini method; combination; fractional inhibitory concentration; herbal medicine; medicinal plant; synergist

Item Type: Article
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Depositing User: marzieye nazari .
Date Deposited: 23 Sep 2019 04:22
Last Modified: 23 Sep 2019 04:22
URI: http://eprints.skums.ac.ir/id/eprint/7902

Actions (login required)

View Item View Item