Local Expression of Mucosal YKL-40; Correlation of YKL-40 with Clinical Manifestations and Immunopathogenesis of Moderate/Severe Persistent Allergic Rhinitis Patients

Pirayesh, A and Shahsavan, S and Zargari Samani, O and Shirzad, H and Amani, S and Bagheri, N and Zamani, M and Torkamand, F and Moghni, M and Deris, F and Khazraei, H and Noormohammadian, Z (2019) Local Expression of Mucosal YKL-40; Correlation of YKL-40 with Clinical Manifestations and Immunopathogenesis of Moderate/Severe Persistent Allergic Rhinitis Patients. Immunol Invest.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/31267789

Abstract

YKL-40 is an important protein that plays a critical role in chronic inflammation in hypersensitivity disease. In this study, the expression of YKL-40 was investigated among patients with moderate/severe persistent allergic rhinitis (M/S PAR), patients with mild (M) PAR and healthy individuals. Moreover, the association between YKL-40 and immunopathogenesis of M/S PAR was meticulously surveyed. For this purpose, surgical samples were tested by real-time polymerase chain reaction to evaluate YKL-40 mRNA expression. The presence and location of YKL-40 protein in the tissue samples were determined by immunohistochemistry. Additionally, we measured the number of eosinophils per field in the tissue samples, blood eosinophils, total serum IgE, specific serum IgE, total nasal syndrome score (TNSS) and YKL-40 serum levels. The data indicated that production of YKL-40 in patients with M/S PAR increased significantly when compared with the control group. Furthermore, local production of YKL-40 correlated with specific IgE, nasal eosinophil count and TNSS. The results of the present study indicate that YKL-40, for its correlation with allergic clinical manifestations and symptom severity in M/S PAR patients, should be considered as a trigger factor in AR

Item Type: Article
Uncontrolled Keywords: M/S PAR, TNSS, YKL-40, allergic rhinitis, disease severity
Subjects: WB Practice of Medicine
WK Endocrine System
WV Otolaryngology
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 07 Jul 2019 04:36
Last Modified: 07 Jul 2019 04:38
URI: http://eprints.skums.ac.ir/id/eprint/7831

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