Role of Regulatory T-cells in Different Clinical Expressions of Helicobacter pylori Infection

Bagheri, N. and Azadegan-Dehkordi, F. and Rahimian, G. and Rafieian-Kopaei, M. and Shirzad, H. (2016) Role of Regulatory T-cells in Different Clinical Expressions of Helicobacter pylori Infection. Archives of Medical Research, 47 (4). pp. 245-254.

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Abstract

Helicobacter pylori (H. pylori) colonization induces vigorous innate and specific immune responses; however, the infection does not disappear and a chronic active gastritis continues if left untreated. It has been shown that the topographical pattern and immune response of gastritis are the main reasons for the bacteria persistence and the clinical outcome. Gastritis due to H. pylori is caused by a complicated interaction among a variety of T cell subsets. Regulatory T (Treg) cells suppressing the immune response of antigen-specific T-cells have recently been demonstrated to play a key role in chronic inflammation by immunologic tolerance. Treg cells have been identified as the major regulatory component of the adaptive immune response and being involved in H. pylori-related inflammation and bacterial persistence. There have been many controversies over the role of Treg cells in H. pylori infection. Many studies have shown that the local Treg response protects the gastric mucosa from intensified inflammation and tissue damage, and the risk of H. pylori-associated diseases has an inverse correlation with Treg accumulation, even if the decrease in the inflammatory response is recognized by Treg it causes increase in bacterial density. This paper reviews the role of Treg in different clinical expressions of H. pylori infection. © 2016 IMSS

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Gastric cancer, Gastritis, Helicobacter pylori, Peptic ulcer, Regulatory T-cells
Subjects: WC Communicable Diseases
WI Digestive System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 05 Jul 2017 04:29
Last Modified: 05 Jul 2017 04:29
URI: http://eprints.skums.ac.ir/id/eprint/782

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