Effects of pentoxifylline and alendronate on fracture healing in ovariectomy-induced osteoporosis in rats

Vashghani Farahani, Mohammad-Mandi and Masteri Farahani, Reza and Abdollahifar, Mohammad-Amin and Ghatresamani, Mahdi and Ghoreishi, Seyed Kamran (2019) Effects of pentoxifylline and alendronate on fracture healing in ovariectomy-induced osteoporosis in rats. VETERINARY RESEARCH FORUM, 10 (2).

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Abstract

Osteoporosis is determined by decreased bone strength that increases the threat of fractures. The aim of this study was to evaluate the effects of pentoxifylline (PTX) and alendronate (ALN), on the stereological parameters, and gene expression in callus of fracture in an experimental rat model of ovariectomy-induced osteoporosis (OVX). The OVX was induced in 90 female rats. Fourteen weeks later, a complete fracture on the right femur was made. Rats were divided into five groups: 1) control: no treatment; 2) sham: received daily distilled water; 3) daily 3.00 mg kg(-1) ALN subcutaneously (SC); 4) daily 200 mg kg(-1) PTX (SC) and 5) daily PTX (SC) + ALN (same doses). The osteoclast count was significantly lower in all treatment groups, at 21 and 56 days post-surgery, compared to the control and sham groups. The PTX significantly increased total callus volume at 21 and 56 days post-surgery, compared to the other groups. The PTX+ALN treatment significantly increased both cortical bone volume on day 21, and osteocyte and osteoblast numbers on day 56, compared to the control and sham groups. It can be concluded that PTX and ALN have antiresorptive effects, in OVX rats. Also, PTX has increased the extracellular matrix on both 21 and 56 days after surgery, compared to the other groups. PTX+ALN elevated cortical bone volume on day 21, and osteocyte and osteoblast numbers compared to the control and sham groups on day 56. (C) 2019 Urmia University. All rights reserved.

Item Type: Article
Uncontrolled Keywords: BONE-FORMATION, NECROSIS-FACTOR, TNF-ALPHA, ESTROGEN, REPAIR, AGENTS, MODEL, IL-6, ACTIVATION, RALOXIFENE
Subjects: QT physiology
WE Musculoskeletal system
QU Biochemistry
QV pharmacology
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 01 Jul 2019 08:25
Last Modified: 02 Jul 2019 03:59
URI: http://eprints.skums.ac.ir/id/eprint/7806

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