Exosomes: Composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Mashouri, L and Yousefi, H and Aref, A and Ahadi, A and Molaei, F and Alahari, S (2019) Exosomes: Composition, biogenesis, and mechanisms in cancer metastasis and drug resistance. Molecular Cancer, 18 (1).

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Official URL: https://www.scopus.com/record/display.uri?eid=2-s2...

Abstract

Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance. Exosomes initiate or suppress various signaling pathways in the recipient cells via transmitting heterogeneous cargoes. In this review we discuss exosome biogenesis, exosome mediated metastasis and chemoresistance. Furthermore, tumor derived exosomes role in tumor microenvironment remodeling, and angiogenesis is reviewed. Also, exosome induction of epithelial mesenchymal transition (EMT) is highlighted. More importantly, we discuss extensively how exosomes regulate drug resistance in several cancers. Thus, understanding exosome biogenesis, their contents and the molecular mechanisms and signaling pathways that are responsible for metastasis and drug-resistance mediated by TDEs may help to devise novel therapeutic approaches for cancer progression particularly to overcome therapy-resistance and preventing metastasis as major factors of cancer mortality.

Item Type: Article
Uncontrolled Keywords: cetuximab, cisplatin, doxorubicin gemcitabine, paclitaxel, platinum derivative, sorafenib, temozolomide
Subjects: WB Practice of Medicine
QZ pathology-Neoplasms
QV pharmacology
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 12 Jun 2019 07:16
Last Modified: 12 Jun 2019 07:17
URI: http://eprints.skums.ac.ir/id/eprint/7776

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