Effects of intermittent fasting on experimental autoimune encephalomyelitis in C57BL/6 mice

Razeghi Jahromi, Soodeh. and Ghaemi, Amir. and Alizadeh, Akram. and Sabetghadam, Fatemeh. and Moradi Tabriz, Hedieh. and Togha, Mansoureh. (2016) Effects of intermittent fasting on experimental autoimune encephalomyelitis in C57BL/6 mice. Iranian Journal of Allergy, Asthma and Immunology, 15 (3). pp. 212-219.

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Abstract

Several religions recommend periods of fasting. One of the most frequently asked questions of MS patients before the holy month of Ramadan is weather fasting might have an unfavorable effect on their disease course. This debate became more challenging after the publication of experimental studies suggesting that calorie restriction prior to disease induction attenuates disease severity. We conducted this study to assess early and late effects of fasting on the animal model of MS, known as autoimmune encephalomyelitis. EAE was induced in the C57BL/6 mice, using Myelin Oligodendrocyte Glycopeptide (MOG) 35-55 and they fasted every other day either after the appearance of the first clinical sign or 30 days after disease induction for ten days. Thereafter, the mice were sacrificed for further histological and immunological evaluations. Intermittent fasting after the establishment of EAE did not have any unfavorable effect on the course of disease. Moreover, fasting at the early phase of disease alleviated EAE severity by ameliorating spinal cord demyelination. Fasting suppressed the secretion of IFN-γ, TNF-α and raised IL-10 production in splenocytes. Fasting was also associated with a lower percent of cytotoxicity. Intermittent fasting not only had no unfavorable effect on EAE but also reduced EAE severity if started at early phase of disease. © Summer 2016, Iran J Allergy Asthma Immunol. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Calorie restriction, Experimental autoimmune encephalomyelitis, Fasting, Immunity, Inflammation ,Multiple sclerosis
Subjects: WL Nervous system
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 05 Jul 2017 03:29
Last Modified: 03 Mar 2018 11:17
URI: http://eprints.skums.ac.ir/id/eprint/776

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