Comparative study of the effect of Thymus daenensis gel 5% and diclofenac in patients with knee osteoarthritis.

Dehghan, M and Asgharian, S and Khalesi, E and Ahmadi, A and Lorigooini, Z (2019) Comparative study of the effect of Thymus daenensis gel 5% and diclofenac in patients with knee osteoarthritis. Biomedicine (Taipei), 9 (2).

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Abstract

BACKGROUND: Osteoarthritis is a syndrome characterized by joint pain and reduced performance and efficien- cy in patient. Thymus daenensis has been used since old times for the treatment of bone and joint deformities and pain in traditional medicine. PURPOSE: This study was conducted to examine traditional usages and pharmacological features of T. daen- ensis with respect to the effect of the plant in patients with osteoarthritis. METHODS: 120 patients with osteoarthritis were divided into 3 groups. Patients in each group were treated by 5% Thymus daenensis gel, 1% diclofenac gel, or placebo for 6 weeks, along with oral celecoxib capsules. Patients were assessed in different intervals, based on the VAS score for assessment of pain in the joint and different dimensions of WOMAC questionnaire. RESULTS: Pain level (P < 0.005), stiffness during the day (P < 0.05), morning stiffness (P < 0.05) and physi- cal performance (P < 0.05) were significantly different among the groups. CONCLUSIONS: Thymus daenensis gel improves the symptoms in patients equal and without significant difference than diclofenac group. It can be argued that its use can produce a satisfactory effect on patients with osteoarthritis due to its low cost, easy access, the plant's natively occurring in Iran.

Item Type: Article
Uncontrolled Keywords: Thymus daenensis gel 5, diclofenac, knee, osteoarthritis
Subjects: WB Practice of Medicine
WE Musculoskeletal system
QV pharmacology
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Orthopedics
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 11 Jun 2019 08:34
Last Modified: 11 Jun 2019 08:34
URI: http://eprints.skums.ac.ir/id/eprint/7750

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