Protective effect of hydro alcoholic extract of Pistacia atlantica against acetaminophen-induced hepatotoxicity and oxidative stress in male rats

Eshaghi, Yaser and Nouri, Ali and Heidarian, Esfandiar and Khaledi, Mansoor and Madmoli, Mostafa and Amini, Sayed Asadollah (2019) Protective effect of hydro alcoholic extract of Pistacia atlantica against acetaminophen-induced hepatotoxicity and oxidative stress in male rats. MEDICAL SCIENCE, 23 (97).

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Abstract

Pistacia atlantica (p.atlantica) has antioxidant, anti-inflammatory and anti-viral properties. This study was undertaken to evaluate the protective effect of P.atlantica against acetaminophen-induced hepatotoxicity in male rats. Forty eight male wistar rats were used in this study. The rats were randomly divided into six groups. Group 1, the control group; group 2, the rats that received acetaminophen only; group3, the rats that received acetaminophen plus silymarin; and groups 4, 5 and 6 were treated with acetaminophen plus p.atlantica extract (200, 400, 800 mg/kg, respectively). At the end of study, the blood specimens and liver samples were examined. In the acetaminophen-only treated group, the levels of serum HDL and liver CAT, SOD and vitamin C significantly decreased compared to control animals. Also, in this group, total cholesterol, TG, LDL, VLDL, protein carbonyl (PC), MDA, serum TNF-alpha and TNF-alpha gene expression significantly increased compared to the control group. Treatment with Pistacia atlantica resulted in a significant increase in CAT, SOD, vitamin C, HDL and a significant decrease in the level of MDA, PC, TG, LDL, VLDL, total cholesterol, serum TNF-alpha, and gene expression of TNF-alpha compared to the acetaminophen-only treated group. The present study suggests that p.atlantica leaves has protective effects against Acetaminophen-induced hepatotoxicity and oxidative stress.

Item Type: Article
Uncontrolled Keywords: LIVER-DAMAGE, ANTIOXIDANT, MICE, MALONDIALDEHYDE, MECHANISMS, EXPRESSION, BIOMARKERS, TOXICITY, INJURY
Subjects: W General medicine- Health professions
WL Nervous system
WM Psychiatry
QU Biochemistry
QV pharmacology
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 09 Jun 2019 09:54
Last Modified: 10 Jun 2019 09:20
URI: http://eprints.skums.ac.ir/id/eprint/7706

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