Evaluation association between PON1 Q192R gene Polymorphisms with Arylesterase activity and plasma level Malondialdehyde in infertile man

Rastegar, Shandokht and Tavakoli, Ramin and Khaledi, Mansoor and Zamani, Mehran and Moradi, Rahim and Nouri, Ali and Madmoli, Mostafa (2019) Evaluation association between PON1 Q192R gene Polymorphisms with Arylesterase activity and plasma level Malondialdehyde in infertile man. MEDICAL SCIENCE, 23 (97).

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Abstract

Objectives: Infertility as a disorder reproductive system and incapacity to achieve a fulfill pregnancy with no contraceptive measures taken after reasonable time of sexual intercourse. PON gene family with paraoxonase, arylesterase, and lactonase activities consists of PON1, PON2 and PON3, are relationship with oxidative stress and lipid metabolism. According the important role of PON1 in oxidative stress and effect active oxygen species on infertility males, aim of this study was evaluation association between PON1 Q192R gene Polymorphisms with arylesterase activity and plasma level malondialdehyde in infertile man. Materials and Methods: In this study blood samples collected from 100 control subjects and 100 infertile men. Q192R variants of PON1 were determined polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique and to estimate the association between genotype and allele frequency in cases and controls, p-values were assessed by chi-square (chi(2)) analysis. In this study, was measurement malondialdehyde by Yagi method as oxidant and arylesterase enzyme as antioxidants in both groups. Results: The founds of this study indicate that the Q allele of PON1 Q192R gene polymorphism is significantly associated with infertility males and infertile individual either homozygote (p <0.029) and heterozygote (p <0.014), have shown a lower Q192R polymorphism, lower Paraoxonase activity and higher level of Malondialdehyde and Arylesterase activity. Conclusion: In the end, we found show the Q192R polymorphism in the PON1 gene is strongly relationship with infertility males and the QQ genotype significant increase risk of idiopathic infertility males unlike RR genotype.

Item Type: Article
Uncontrolled Keywords: Infertility, Paraoxonase, Arylesterase, Polymorphism Q192R, Malondialdehyde
Subjects: W General medicine- Health professions
WP Gynecology
QZ pathology-Neoplasms
Divisions: Reserach Vice-Chancellar Department > Journal of Clinical Nursing and Midwifery
Journal of Clinical Nursing and Midwifery
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 09 Jun 2019 09:37
Last Modified: 10 Jun 2019 09:17
URI: http://eprints.skums.ac.ir/id/eprint/7705

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