Effect of experimental diabetes mellitus on some biochemical parameters and histopathological changes in pancreas, liver, kidney, and lung in ovariectomized rats

Namjoo, Abdolrasoul. and Heidarian, Esfandiar. and Rafieian-Kopaei, Mahmoud. and Safarian, Mehrdad. (2016) Effect of experimental diabetes mellitus on some biochemical parameters and histopathological changes in pancreas, liver, kidney, and lung in ovariectomized rats. Journal of Mazandaran University of Medical Sciences, 26 (138). pp. 1-16.

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Abstract

Background and purpose: Menopause is a physiological process and diabetes is a metabolic disease that occurs more frequently in older women. The present study investigated the effects of diabetes on some biochemical parameters and histopathological changes in ovariectomized rats. Materials and methods: Thirty two adult female rats were divided into four groups of 8 and studied for 55 weeks. The animals were assigned into a control group, an ovariectomized group (55 weeks), a third group in which diabetes was induced in the last 5 weeks of the study in rats with intact ovary. The next group included ovariectomized rats (for 55 weeks) in which diabetes was induced in the last 5 weeks of the study. Pathological alterations of liver, kidney, pancreas, lung and some serum biochemical parameters were determined in each group at the end of the study. Results: Diabetic and diabetic ovariectomized rats showed increase in serum levels of blood glucose, AST, ALT, GGT, ALP, calcium, urea, TG and HDL compared with the control group (P< 0.05). Increased serum levels of LDH, TG, cholesterol, HDL, LDL were seen in ovariectomized rats compared with the control group (P< 0.05). Pathological examinations revealed changes in all groups except in the control group. Conclusion: Our findings suggest that long term reduction of estrogen in ovariectomized diabetic rats can reduce the serum levels of glucose, AST, ALT, GGT, urea, VLDL and triglycerides compared with non ovariectomized diabetic rats.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Diabetesو Menopauseو Ovariectomyو Rats
Subjects: WP Gynecology
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 04 Jul 2017 09:51
Last Modified: 29 May 2018 06:26
URI: http://eprints.skums.ac.ir/id/eprint/770

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