Attenuating effect of Portulaca oleracea extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative and anti-inflammatory properties.

Forouzanfar, F and Hosseinzadeh, H and Khorrami, M and Asgharzade, S and Rakhshandeh, H (2019) Attenuating effect of Portulaca oleracea extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative and anti-inflammatory properties. CNS Neurol Disord Drug Targets.

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Official URL: http://www.eurekaselect.com/170714/article

Abstract

Neuropathic pain responds poorly to drug treatments. The present study investigated the therapeutic effect of Portulaca oleracea, in chronic constriction injury (CCI)-induced neuropathic pain in rats. Neuropathic pain was performed by putting four loose ligatures around the sciatic nerve. CCI resulted in the development of heat hyperalgesia, mechanical allodynia and cold allodynia accompanied by an increase in the contents of TNF-α, IL1β, malondialdehyde, with a reduction in total thiol content. Administration of Portulaca oleracea (100 and 200 mg/kg intraperitoneal) for 14 days in CCI rats significantly alleviated pain-related behaviors, oxidative damage and inflammatory cytokines in a dose-dependent manner. In conclusion, it is suggested that antinociceptive effects of Portulaca oleracea might be due to antioxidant and anti-inflammatory properties.

Item Type: Article
Uncontrolled Keywords: Antinociceptive effect, Hyperalgesia., Neuropathic pain, Portulaca oleracea
Subjects: WB Practice of Medicine
WL Nervous system
QV pharmacology
QY Clinical Pathology
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Psychiatry
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 08 Apr 2019 03:56
Last Modified: 14 Apr 2019 03:45
URI: http://eprints.skums.ac.ir/id/eprint/7621

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