Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

Nourian Dehkordi, A and Mirahmadi Babaheydari, F and Chehelgerdi, M and Raeisi Dehkordi, S (2019) Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies. Stem Cell Res Ther, 10 (1).

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Normal wound healing is a dynamic and complex multiple phase process involving coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure in these phases may lead wounds to become chronic and have abnormal scar formation. Chronic wounds affect patients' quality of life, since they require repetitive treatments and incur considerable medical costs. Thus, much effort has been focused on developing novel therapeutic approaches for wound treatment. Stem-cell-based therapeutic strategies have been proposed to treat these wounds. They have shown considerable potential for improving the rate and quality of wound healing and regenerating the skin. However, there are many challenges for using stem cells in skin regeneration. In this review, we present some sets of the data published on using embryonic stem cells, induced pluripotent stem cells, and adult stem cells in healing wounds. Additionally, we will discuss the different angles whereby these cells can contribute to their unique features and show the current drawbacks.

Item Type: Article
Uncontrolled Keywords: Chronic wounds, Cytokines, Growth factors, Skin, Stem cells, Wound healing
Subjects: WA Public Health
WB Practice of Medicine
WL Nervous system
WR Dermatology
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Dermatology
Depositing User: Unnamed user with email
Date Deposited: 07 Apr 2019 09:42
Last Modified: 08 Apr 2019 03:49

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