Human unrestricted somatic stem cells ameliorate sepsis-related acute lung injury in mice

Behjani, Z and Ai, J and Soleimani, M and Atashi, A and Taheri, B and Ebrahimi-Barough, S and Siavashi, V and Shirian, S and Hamidieh, A (2019) Human unrestricted somatic stem cells ameliorate sepsis-related acute lung injury in mice. Journal of Cellular Physiology.

[img]
Preview
Text
zarei.pdf

Download (854kB) | Preview

Abstract

Background Aims: Sepsis and related disorders, especially acute lung injury (ALI), are the most challenging life-threatening diseases in the hospital intensive care unit. Complex pathophysiology, unbalanced immune condition, and high rate of mortality complicate the treatment of sepsis. Recently, cell therapy has been introduced as a promising option to recover the sepsis symptoms. The aim of this study was to investigate the therapeutic potential of human unrestricted somatic stem cells (USSCs) isolated from human umbilical cord blood in the mouse model of ALI. USSCs significantly enhanced the survival rate of mice suffering from ALI and suppressed concentrations of proinflammatory mediators TNF-α, and interleukin (IL)-6, and the level of anti-inflammatory cytokine IL-10. ALI mice injected by USSCs showed notable reduction in lung and liver injury, pulmonary edema, and hepatic enzymes, compared with the control group. These results determined the in vivo immunomodulatory effect of USSCs for recovery of immune balance and reduction of tissue injury in the mouse model of ALI. Therefore, USSCs can be a suitable therapeutic approach to manage sepsis disease through the anti-inflammatory potential

Item Type: Article
Uncontrolled Keywords: acute lung injury, cell therapy, inflammation, umbilical cord, unrestricted somatic stem cells
Subjects: WB Practice of Medicine
WF Respiratory System
WL Nervous system
QY Clinical Pathology
QY Clinical Pathology > QZ Pathology
Divisions: Reserach Vice-Chancellar Department > Social Determinants of Health Research Center
Reserach Vice-Chancellar Department > University of Management Conferences and Congresses
Reserach Vice-Chancellar Department > student research center
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 07 Apr 2019 07:32
Last Modified: 16 Apr 2019 08:35
URI: http://eprints.skums.ac.ir/id/eprint/7611

Actions (login required)

View Item View Item