Cardiac chronotropic hypo-responsiveness and atrial fibrosis in rats chronically treated with lithium

Moradi, S and Aminian, A and Abdollahi, A and Jazayeri, A and Ghamami, G and Nikoui, V and Bakhtiarian, A and Jazaeri, F (2019) Cardiac chronotropic hypo-responsiveness and atrial fibrosis in rats chronically treated with lithium. Autonomic Neuroscience: Basic and Clinical, 216.


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Lithium is a widely used mood-stabilizing agent; however, it causes a variety of cardiovascular side effects including sinus node dysfunction. In this study we explored the potential adverse effects of lithium on cardiac chronotropic responsiveness, atrial tissue histology and gene expression in rats that were chronically treated with therapeutic doses of lithium. Male Wistar albino rats were given lithium chloride (2.5 g/kg) orally for 2 or 3 months. Following treatment, the atria were isolated and spontaneously beating rate and chronotropic responsiveness to β-adrenergic stimulation was evaluated in an organ bath. Development of cardiac fibrosis was examined by histological methods. The expression of atrial Col1a1 (collagen I, alpha 1) and β-arrestin2 was also assessed using quantitative RT-PCR. Treatment with lithium induced a significant hypo-responsiveness to adrenergic stimulation (P < 0.001) and caused fibrosis in the atrial tissue of treated rats. In addition, the expression of atrial Col1a1 mRNA was significantly increased in atrial tissues of lithium-treated animals, while β-arrestin2 mRNA expression did not show a significant difference compared with control animals. Altogether, these findings indicate that cardiac chronotropic hypo responsiveness and associated cardiac fibrosis are side effects of chronic lithium treatment. Moreover, it seems that lithium treatment does not influence β-arrestin2 mRNA expression

Item Type: Article
Uncontrolled Keywords: Bipolar disorder, Cardiac fibrosis, Chronotropic response, Lithium, β-Arrestin
Subjects: QS Human Anatomy
QS Human Anatomy
university Structure > QS Human Anatomy

QT physiology
WB Practice of Medicine
WG Cardiovascular System
WH Hemic and Lymphatic System
QU Biochemistry
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Cardiology
Depositing User: Unnamed user with email
Date Deposited: 07 Apr 2019 05:46
Last Modified: 17 Apr 2019 04:03

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