Natural infection with rabies virus: A histopathological and immunohistochemical study of human brains

Farahtaj, F and Alizadeh, L and Gholami, A and Tahamtan, A and Shirian, S and Fazeli, M and Nejad, A and Gorji, A and Niknam, H and Ghaemi, A (2019) Natural infection with rabies virus: A histopathological and immunohistochemical study of human brains. Osong Public Health and Research Perspectives, 10 (1).

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Abstract

Objectives: Despite all the efforts and increased knowledge of rabies, the exact mechanisms of infection and mortality from the rabies virus are not well understood. To understand the mechanisms underlying the pathogenicity of rabies virus infection, it is crucial to study the tissue that the rabies virus naturally infects in humans. Methods: Cerebellum brain tissue from 9 human post mortem cases from Iran, who had been infected with rabies virus, were examined histopathologically and immunohistochemically to evaluate the innate immune responses against the rabies virus. Results: Histopathological examination revealed inflammation of the infected cerebellum and immunohistochemical analyses showed an increased immunoreactivity of heat shock protein 70, interleukin-6, interleukin-1, tumor necrosis factor-alpha, caspase-3, caspase-9, toll-like receptor3 and toll-like receptor4 in the infected brain tissue. Conclusion: These results indicated the involvement of innate immunity in rabies infected human brain tissue, which may aggravate the progression of this deadly disease. © 2019 Korea Centers for Disease Control and Prevention. This is an open access article under the CC BY-NC-ND license

Item Type: Article
Uncontrolled Keywords: Central nervous system, Human, Immunohistochemistry, Pathology, Rabies, Tissue
Subjects: WB Practice of Medicine
WL Nervous system
QZ pathology-Neoplasms
QW Microbiology and Immunology
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Infectious Diseases
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 07 Apr 2019 03:54
Last Modified: 16 Apr 2019 09:07
URI: http://eprints.skums.ac.ir/id/eprint/7596

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