miR-455-5p downregulation promotes inflammation pathways in the relapse phase of relapsing-remitting multiple sclerosis disease

Torabi, S and Tamaddon, M and Asadolahi, M and Shokri, G and Tavakoli, R and Tasharrofi, N and Rezaei, R and Tavakolpour, V and Sazegar, H and Kouhkan, F (2019) miR-455-5p downregulation promotes inflammation pathways in the relapse phase of relapsing-remitting multiple sclerosis disease. Immunogenetics, 71 (2).

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Abstract

MicroRNA-455-5p (miR-455-5p) seems to have an anti-inflammatory role in the immune system since its expression is induced by IL-10 cytokine. Multiple sclerosis (MS) is a chronic demyelinating neurodegenerative disease of the central nervous system that is caused by an autoimmune inflammatory attack against the myelin insulation of neurons. The expression level of miR-455-5p and its role in MS pathogenesis has yet to be elucidated. We found that miR-455-5p expression was highly correlated with disease severity in MS patients. miR-455-5p expression inversely correlates with its inflammatory-predicted targets (MyD88 and REL) in relapse- and remitting-phase patients. Luciferase assays confirm that MyD88 and REL are direct targets of miR-455-5p. This study represents the first report of the miR-455-5p acts as an anti-inflammatory role in MS, at least partially through targeting MyD88 and REL. This study may provide important information for the use of miR-455-5p as a novel strategy to improve the severity of disease and control inflammation and attack in MS patients. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.

Item Type: Article
Uncontrolled Keywords: Inflammation, miR-455-5p, Multiple sclerosis, MyD88REL
Subjects: WB Practice of Medicine
WD Nutrition Disease and metabolic diseases
WE Musculoskeletal system
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 06 Apr 2019 09:47
Last Modified: 08 Apr 2019 06:45
URI: http://eprints.skums.ac.ir/id/eprint/7592

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