Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies

Parizadeh SM, SM and Rezayi M, M and Jafarzadeh-Esfehani R, R and Avan A, A and Ghazizadeh H, H and Emadzadeh M, M and Sahebi R, R and Ferns GA, GA and Ghayour-Mobarhan M, M (2018) Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies. Int J Vitam Nutr Res.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30816821

Abstract

BACKGROUND: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran. METHODS: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. RESULTS: Vitamin D insufficiency, or deficiency (VDD), is highly prevalent in Iran, reports varying between 44.4% in Isfahan to 98% in Gorgan. There is also a high prevalence of VDD among patients with liver or kidney disease, and the administration of vitamin D supplements may have beneficial effects on lipid profile, blood glucose, liver function and fatty liver disease, and bone health. Low serum vitamin D levels are related with abnormalities in these laboratory and clinical parameters. CONCLUSION: VDD is prevalent in patients with chronic liver or renal disease in Iran. There appear to be several beneficial effects of vitamin D supplementation in vitamin D deficient patients with liver or kidney disease.

Item Type: Article
Uncontrolled Keywords: Iran, Kidney disease, Liver disease, Vitamin D deficiency
Subjects: WD Nutrition Disease and metabolic diseases
WI Digestive System
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 11 Mar 2019 05:31
Last Modified: 23 Apr 2019 03:25
URI: http://eprints.skums.ac.ir/id/eprint/7566

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