Herbal medicine as an auspicious therapeutic approach for the eradication of Helicobacter pylori infection: A concise review

Ghasemian A, A and Fattahi A, A and Shokouhi Mostafavi S, S and Almarzoqi AH, AH and Memariani M, M and Ben Braiek O, O and Cresswell-Boyes AJ, AJ and Yassine HM, HM and Mostafavi NSS, NSS and Ahmed MM, MM and Mirforughi SA, SA (2019) Herbal medicine as an auspicious therapeutic approach for the eradication of Helicobacter pylori infection: A concise review. J Cell Physiol.


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Helicobacter pylori (H. pylori) causes gastric mucosa inflammation and gastric cancer mostly via several virulence factors. Induction of proinflammatory pathways plays a crucial role in chronic inflammation, gastric carcinoma, and H. pylori pathogenesis. Herbal medicines (HMs) are nontoxic, inexpensive, and mostly anti-inflammatory reminding meticulous emphasis on the elimination of H. pylori and gastric cancer. Several HM has exerted paramount anti-H. pylori traits. In addition, they exert anti-inflammatory effects through several cellular circuits such as inhibition of 5'-adenosine monophosphate-activated protein kinase, nuclear factor-κB, and activator protein-1 pathway activation leading to the inhibition of proinflammatory cytokines (interleukin 1α [IL-1α], IL-1β, IL-6, IL-8, IL-12, interferon γ, and tumor necrosis factor-α) expression. Furthermore, they inhibit nitrous oxide release and COX-2 and iNOS activity. The apoptosis induction in Th1 and Th17-polarized lymphocytes and M2-macrophagic polarization and STAT6 activation has also been exhibited. Thus, their exact consumable amount has not been revealed, and clinical trials are needed to achieve optimal concentration and their pharmacokinetics. In the aspect of bioavailability, solubility, absorption, and metabolism of herbal compounds, nanocarriers such as poly lactideco-glycolide-based loading and related formulations are helpful. Noticeably, combined therapies accompanied by probiotics can also be examined for better clearance of gastric mucosa. In addition, downregulation of inflammatory microRNAs (miRNAs) by HMs and upregulation of those anti-inflammatory miRNAs is proposed to protect the gastric mucosa. Thus there is anticipation that in near future HM-based formulations and proper delivery systems are possibly applicable against gastric cancer or other ailments because of H. pylori.

Item Type: Article
Uncontrolled Keywords: Helicobacter pylori, gastric cancer, inflammation, phytomedicine, therapeutic regimens
Subjects: WC Communicable Diseases
QV pharmacology
QW Microbiology and Immunology
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Microbiology
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 11 Mar 2019 04:47
Last Modified: 10 Apr 2019 04:43
URI: http://eprints.skums.ac.ir/id/eprint/7563

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