Causes and consequences of microRNA dysregulation following cerebral ischemia-reperfusion injury

Forouzanfar F, F and Shojapour M, M and Asgharzade S, S and Amini E, E (2019) Causes and consequences of microRNA dysregulation following cerebral ischemia-reperfusion injury. CNS Neurol Disord Drug Targets.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30714533

Abstract

Stroke continues to be a major cause of death and disability worldwide. In this respect, the most important mechanisms underlying stroke pathophysiology are inflammatory pathways, oxidative stress, as well as apoptosis. Accordingly, miRNAs are considered as non-coding endogenous RNA molecules interacting with their target mRNAs to inhibit mRNA translation or reduce its transcription. Studies in this domain have similarly shown that miRNAs are strongly associated with coronary artery disease and correspondingly contribute to the brain ischemia molecular processes. To retrieve articles related to the study subject, i.e. the role of miRNAs involved in inflammatory pathways, oxidative stress, and apoptosis in stroke from the databases of Web of Science, PubMed (NLM), Open Access Journals, LISTA (EBSCO), and Google Scholar; keywords including cerebral ischemia, microRNA (miRNA), inflammatory pathway, oxidative stress, along with apoptosis were used. It was consequently inferred that, miRNAs could be employed as potential biomarkers for diagnosis and prognosis, as well as therapeutic goals of cerebral ischemia

Item Type: Article
Uncontrolled Keywords: Inflammatory Pathways, MiRNAs, Oxidative Stress, Stroke, apoptosis
Subjects: WL Nervous system
QZ pathology-Neoplasms
Divisions: Faculty of Medicine > School of Psychology
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 12 Feb 2019 06:45
Last Modified: 16 Apr 2019 09:19
URI: http://eprints.skums.ac.ir/id/eprint/7531

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