Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules

Fadaei, R and Dadmanesh, M and Moradi, N and Ahmadi, R and Shokoohi Nahrkhalaji, A and Aghajani, H and Ghorban, K (2018) Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules. Arch Physiol Biochem.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30463448

Abstract

Subfatin is a newly discovered adipokine with insulin-sensitizing properties. Studies reported conflicting data with regard to the circulating levels and expression of Subfatin in the context of type 2 diabetes mellitus (T2DM) and obesity. The present study was conducted on 52 patients with T2DM, 36 prediabetes subjects, and 50 controls. The serum levels of Subfatin, adhesion molecules were measured by the ELISA technique. The serum Subfatin was lower in the T2DM and prediabetes groups. The serum levels of adhesion molecules were higher in the T2DM group. In addition, Subfatin demonstrated lower levels in obese patients with T2DM in comparison to lean T2DM patients. Furthermore, Subfatin showed a negative association with vascular adhesion molecules in prediabetes subjects and the T2DM group. A decrease in the serum Subfatin in T2DM patients and prediabetes subjects, and its association with vascular adhesion molecules suggested the possible role of Subfatin in diabetes and endothelial dysfunction

Item Type: Article
Uncontrolled Keywords: E-selectin, ICAM-1, Subfatin/meteorin-like, VCAM-1, endothelial dysfunction
Subjects: WD Nutrition Disease and metabolic diseases
WE Musculoskeletal system
QV pharmacology
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 24 Dec 2018 05:08
Last Modified: 20 Apr 2019 03:53
URI: http://eprints.skums.ac.ir/id/eprint/7454

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