Association between microRNAs expression and signaling pathways of inflammatory markers in diabetic retinopathy

Shafabakhsh, R and Aghadavod, E and Mobini, M and Heidari-Soureshjani, R and Asemi, Z (2018) Association between microRNAs expression and signaling pathways of inflammatory markers in diabetic retinopathy. J Cell Physiol.

Full text not available from this repository.
Official URL: https://www.researchgate.net/publication/329215803...

Abstract

Diabetic retinopathy is one of the common and serious microvascular complications of diabetes mellitus, as hyperglycemia has metabolic effects on the retina. Hyperglycemia induces increased oxidative stress, which stimulates inflammation pathways and promotes vascular dysfunction of the retina that leads to increased capillary permeability and vascular leakage. One of the main factors involving diabetic retinopathy is the inflammation signaling pathways. In contemporary times, microRNAs (miRNAs) are identified as functional biomarkers for early detection and treatment of numerous diseases specifically diabetic retinopathy. MiRNAs can modulate gene expression through regulation of transcriptional and posttranscriptional of target genes. With that, miRNAs can regulate almost every cellular and developmental process, including the regulation of instinct immune responses and inflammation. The aim of this study is to investigate the role of miRNAs in inflammation pathways and the pathogenesis of diabetic retinopathy

Item Type: Article
Uncontrolled Keywords: diabetic retinopathy, inflammation pathway, miRNAs
Subjects: WD Nutrition Disease and metabolic diseases
WH Hemic and Lymphatic System
WK Endocrine System
QZ pathology-Neoplasms
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 23 Dec 2018 08:32
Last Modified: 23 Apr 2019 06:23
URI: http://eprints.skums.ac.ir/id/eprint/7452

Actions (login required)

View Item View Item