The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats

Hasanvand, A and Ahmadizar, F and Abbaszadeh, A and Amini-Khoei, H and Goudarzi, M and Abbasnezhad, A and Choghakhori, R (2018) The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats. Basic Clin Neurosci, 9 (4).

[img] Text
BCN-9-251.pdf

Download (1MB)

Abstract

Introduction: According to studies, statins possess analgesics and anti-inflammatory properties. In the present study, we examined the antinociceptive, anti-inflammatory and antioxidative effects of rosuvastatin in an experimental model of Chronic Constriction Injury (CCI). Methods: Our study was conducted on four groups; sham, CCI (the control group), CCI+rosuvastatin (i.p. 5 mg/kg), and CCI+rosuvastatin (i.p. 10 mg/kg). We performed heat hyperalgesia, cold and mechanical allodynia tests on the 3rd, 7th, 14th, and 21st after inducing CCI. Blood samples were collected to measure the serum levels of Tumor Necrosis Factor (TNF)-α, and Interleukin (IL)-6. Rats' spinal cords were also examined to measure tissue concentration of Malondialdehyde (MDA), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) enzymes. Results: Our findings showed that CCI resulted in significant increase in heat hyperalgesia, cold and mechanical allodynia on the 7th, 14th and 21st day. Rosuvastatin use attenuated the CCI-induced hyperalgesia and allodynia. Rosuvastatin use also resulted in reduction of TNF-α, IL-6, and MDA levels. However, rosuvastatin therapy increased the concentration of SOD and GPx in the CCI+Ros (5 mg/kg) and the CCI+Ros (10 mg/kg) groups compared to the CCI group. Conclusion: Rosuvastatin attenuated the CCI-induced neuropathic pain and inflammation. Thus, antinociceptive effects of rosuvastatin might be channeled through inhibition of inflammatory biomarkers and antioxidant properties

Item Type: Article
Uncontrolled Keywords: Chronic Constriction Injury (CCI), Neuralgia, Rats, Rosuvastatin
Subjects: WB Practice of Medicine
WH Hemic and Lymphatic System
QZ pathology-Neoplasms
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 17 Dec 2018 10:21
Last Modified: 17 Dec 2018 10:21
URI: http://eprints.skums.ac.ir/id/eprint/7440

Actions (login required)

View Item View Item