Gonorrhea and syphilis co-infection and related risk factors in HIV patients from Shiraz, South of Iran

Ghassabi, Farzaneh and Malekzadegan, Yalda and Ebrahim-Saraie, Hadi Sedigh and Heidari, Hamid and Sabet, Mozhgan and Bagheri, Abdollatif (2018) Gonorrhea and syphilis co-infection and related risk factors in HIV patients from Shiraz, South of Iran. CASPIAN JOURNAL OF INTERNAL MEDICINE, 9 (4).

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Abstract

Background: Neisseria gonorrhea and Treponema pallidum as an obligate human pathogen are two common causes of sexually transmitted diseases (STDs). The present study aimed to determine the prevalence of N. gonorrhoeae and T. pallidum among human immunodeficiency virus (HIV) patients in the southwest Iran. Methods: This retrospective study was performed from 2004 to 2013, on HIV patients who were tested for detection of gonorrhea and syphilis infection at Shiraz HIV/AIDS Research Center. ELISA technique was used for preliminary detection of HIV and confirmed by a Western Blotting test. Gonorrhea was routinely diagnosed using direct Gram-staining and culturing on selective agar. Syphilis was routinely diagnosed by RPR test. Results: Of the 806 HIV patients, 39 (2.6%) cases had co-infection with gonorrhea. Compared with mono-HIV infected patients, gonorrhea was significantly more likely among the males (69.4% vs. 92.3%, P=0.002). History of addiction and prison seems to be a significant risk factor for gonorrhea infection (P<0.05). Also, the mean of CD4+lymphocyte was higher among gonorrhea infected patients (368 +/- 238 vs. 415 +/- 328). Logistic regression analysis showed that sexual contact increased risk of gonococcal infection about 4 fold (OR: 4, CI: 1.7-9.39, P=0.001). None of the HIV patients had syphilis co-infection. Conclusions: As a preliminary survey, our findings provided unique information on the prevalence of gonorrhea and syphilis co-infections among HIV patients. Moreover, we introduced the main risk factors associated with gonorrhea co-infection in HIV patients in our region including gender, history of addiction and prison, CD4+lymphocyte count, and transmission routes for effective management of STDs.

Item Type: Article
Uncontrolled Keywords: SEXUALLY-TRANSMITTED INFECTIONS, FEMALE SEX WORKERS, PREVALENCE, WOMEN, CHLAMYDIA, TEHRAN
Subjects: WA Public Health
QZ pathology-Neoplasms
QW Microbiology and Immunology
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 17 Dec 2018 05:54
Last Modified: 17 Dec 2018 05:54
URI: http://eprints.skums.ac.ir/id/eprint/7435

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