The effect of luteal phase gonadotropin-releasing hormone antagonist administration on IVF outcomes in women at risk of OHSS

Eftekhar, M. and Miraj, S. and Mortazavifar, Z. (2016) The effect of luteal phase gonadotropin-releasing hormone antagonist administration on IVF outcomes in women at risk of OHSS. International Journal of Reproductive BioMedicine, 14 (8). pp. 507-510.

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Abstract

Gonadotropin-releasing hormone (GnRH) plays essential roles in embryo implantation, invasion of trophoblastic tissue, and steroid synthesis in the placenta. Objective: The aim of this study was to evaluate the effect of GnRH antagonist administration on pregnancy outcomes in early implantation period. Materials and Methods: In this retrospective study, 94 infertile women undergoing GnRH antagonist protocol who were at risk of ovarian hyperstimulation syndrome (OHSS) were included. Sixty-seven patients (group I) received Cetrorelix 0.25 mg/daily in the luteal phase for 3 days while in 27 participants (group II), it was not administered. Pregnancy outcomes were assessed based on chemical and clinical pregnancy rates. Results: The pregnancy outcomes were not significantly different between two groups (p=0.224). Conclusion: The present study proposed that luteal phase GnRH antagonist administration does not influence the chance of successful pregnancy outcomes.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: Gonadotropin-releasing hormone antagonistو In vitro fertilizationو Pregnancy outcome
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Obstetrics and Gynecology
Depositing User: zahra bagheri .
Date Deposited: 04 Jul 2017 05:34
Last Modified: 04 Jul 2017 05:34
URI: http://eprints.skums.ac.ir/id/eprint/742

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