Cellular and molecular mechanisms of sulfur mustard toxicity on spermatozoa and male fertility

Beigi Harchegani, Asghar and Niha, Mahdiyeh Mirnam and Ghatrehsamani, Mahdi and Tahmasbpour, Eisa and Shahriary, Alireza and Sohrabiyan, Milad (2018) Cellular and molecular mechanisms of sulfur mustard toxicity on spermatozoa and male fertility. TOXICOLOGY RESEARCH.

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ToxicologyResearchVolumeissue2018doi10.1039_C8TX00062JBeigiHarcheganiAsgharMirnamNihaMahdiyehSohrabiyanMil--Cellularandmolecularmechanismsofsulfurmustardtoxicityonspe.pdf

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Abstract

Sulfur mustard (SM) is a toxic compound that can target human spermatozoa. SM induces a wide variety of pathological effects in human reproductive organs, including sexual hormone disturbance, testicular atrophy, impaired spermatogenesis, poor sperm quality, defects in embryo development, childhood physical abnormalities, and severe fertility problems. However, the molecular and cellular mechanisms of SM action on male reproductive health and human sperm function are unclear. Excessive production of reactive oxygen species and the resulting oxidative stress is likely a significant mechanism of SM action, and could be associated with sperm DNA damage, membrane lipid peroxidation, reduced membrane fluidity, mitochondrial deficiency, apoptosis, and poor sperm quality. In this review, we aim to discuss the cellular and molecular mechanisms of SM action on sperm and reproductive health, the significance of OS, and the mechanisms through which SM enhances the infertility rate among SM-exposed individuals.

Item Type: Article
Uncontrolled Keywords: INTOXICATED IRANIAN VETERANS; LONG-TERM COMPLICATIONS; PULMONARY-FUNCTION TEST, GAS-EXPOSED PATIENTS, CHRONIC SKIN-LESIONS, OXIDATIVE STRESS, MALE-INFERTILITY, DNA-DAMAGE, SPERM QUALITY, HISTORICAL COHORT
Subjects: QV pharmacology
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 01 Dec 2018 09:24
Last Modified: 22 Apr 2019 09:13
URI: http://eprints.skums.ac.ir/id/eprint/7410

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