Hepatoprotective effect of Descurainia sophia seed extract against paracetamol-induced oxidative stress and hepatic damage in mice

Moshaie-Nezhad, Pedram and Iman, Maryam and Faed Maleki, Firouz and Khamesipour, Ali (2018) Hepatoprotective effect of Descurainia sophia seed extract against paracetamol-induced oxidative stress and hepatic damage in mice. J Herbmed Pharmacol, 7 (4).

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Abstract

Introduction: In this study, we aimed to evaluate the protective effects of Descurainia sophia seed extract on paracetamol-induced oxidative stress and acute liver injury in mice. Methods: Sixty male Swiss albino mice were divided into 6 groups, group I: as control group received NaCl 9%. Group II: as paracetamol group received paracetamol intraperitoneally (i.p.) (500 mg/kg). Groups III to VI as treatment groups received different doses of D. sophia seed extract (T1 = 50, T2 = 100, T3 = 200 and T4 = 300 mg/kg, respectively). Twenty-four hours after the paracetamol administration, the mice were sacrificed under mild anesthesia and their blood samples were collected to estimate serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin and malondialdehyde (MDA) levels. Their livers were also removed for histopathological examinations. Results: Pretreatment of mice with D. sophia seed extract, significantly prevented the paracetamol induced elevation in the levels of serum ALT, AST and ALP, total bilirubin and MDA (P < 0.05). The results of histopathologic studies were consistent with the above findings. Conclusion: Descurainia sophia seed extract has a protective effect against paracetamol induced oxidative damage and acute hepatotoxicity in mice.

Item Type: Article
Uncontrolled Keywords: Descurainia sophia, Hepatotoxicity. Medicinal plant Oxidative stress, Hepato-protective effect
Subjects: WD Nutrition Disease and metabolic diseases
WL Nervous system
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 20 Nov 2018 09:08
Last Modified: 20 Nov 2018 09:08
URI: http://eprints.skums.ac.ir/id/eprint/7385

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