Effect of gallic acid on chronic restraint stress-induced anxiety and memory loss in male BALB/c mice

Salehi, A and Rabiei, Z and Setorki, M (2018) Effect of gallic acid on chronic restraint stress-induced anxiety and memory loss in male BALB/c mice. Iranian Journal of Basic Medical Sciences, 21 (12).

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Abstract

Objective(s): Long-term exposure to stress leads to memory deficits and certain mood disorders such as depression and anxiety. We aimed to study the effect of gallic acid (GA) on chronic restraint stress (CRS) induced anxiety and memory deficits in male BALB/c mice. Materials and Methods: Ninety male BALB/c mice were assigned to nine groups including caged control (CC): food-water deprived (FWD), under chronic restraint stress (CRS), CRS+ gallic acid (5, 10, and 20 mg/ kg), and gallic acid (5, 10, and 20 mg/kg). Behavioral assays were performed after 21 days of daily treatment with CRS and GA. Serum and brain levels of malondialdehyde (MDA) and total antioxidant capacity (TCA) and serum corticosterone level were also measured. Results: Treatment of CRS mice with GA significantly improved passive avoidance memory in the shuttle box and ameliorated anxiety-like behaviors in the elevated plus maze (EPM) and open filed test (OFT). GA treatment significantly reduced elevated levels of serum and brain MDA and increased brain TCA. CRS and GA did not affect serum corticosterone levels. Treatment of healthy mice with GA had some adverse effects and induced some anxiety and oxidative stress. Conclusion: GA exerted protective effects against stress-induced mood and memory deficit disorders.

Item Type: Article
Uncontrolled Keywords: Anxiety, Gallic acid, Malondialdehyde, Oxidative stress, Passive avoidance memory
Subjects: WD Nutrition Disease and metabolic diseases
WM Psychiatry
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 14 Nov 2018 07:12
Last Modified: 23 Apr 2019 05:12
URI: http://eprints.skums.ac.ir/id/eprint/7369

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