Yaghoobi, Hajar and Azizi, Hakim and Kholghi Oskooe, Vahid and Taheri, Mohammad and Ghafouri-Fard, oudeh (2018) Assessment of expression of interferon γ (IFN-G) gene and its antisense (IFNG-AS1) in breast cancer. World J Surg Oncol.
|
Text
Assessment of expression of.pdf Download (695kB) | Preview |
Abstract
Background The role of long non-coding RNAs has been extensively appreciated in the contexts of cancer. Interferon γ-antisense RNA1 (IFNG-AS1) is an lncRNA located near to IFN-γ-encoding (IFNG) gene and regulates expression of IFNG in Th1 cells. Methods In the present study, we evaluated expression of IFNG and IFNG-AS1 in 108 breast samples including tumoral tissues and their adjacent non-cancerous tissues (ANCTs) using real-time PCR. IFNG-AS1 was significantly upregulated in tumoral tissues compared with ANCTs (expression ratio = 2.23, P = 0.03). Results Although the expression of IFNG was higher in tumoral tissues compared with ANCTs (relative expression = 1.89), it did not reach the level of significance (P = 0.07). IFNG expression was significantly higher in HER2-negative tumoral tissues compared with HER2-positive ones (P = 0.01) and in grade 1 samples compared with grade 2 ones (P = 0.03). No other significant difference was found in expressions of genes between other groups. Conclusion Significant strong correlations were detected between expression of IFNG and IFNG-AS1 in both tumoral tissues and ANCTs. The present study provides evidences for participation of IFNG and IFNG-AS1 in the pathogenesis of breast cancer and warrants future studies to elaborate the underlying mechanism.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Breast cancer, IFNG, IFNG-AS1 |
Subjects: | WM Psychiatry WP Gynecology QZ pathology-Neoplasms |
Divisions: | Faculty of Medicine |
Depositing User: | Unnamed user with email nazari@skums.ac.ir |
Date Deposited: | 14 Nov 2018 05:13 |
Last Modified: | 14 Nov 2018 05:13 |
URI: | http://eprints.skums.ac.ir/id/eprint/7363 |
Actions (login required)
![]() |
View Item |