Serum concentration of hs-CRP in obese individuals with and without metabolic syndrome and its association with parameters of metabolic syndrome

Mirhoseini, Mahmood and Daemi, Hamid and Babaiee, Mahshid Masoom and Asadi-Samani, Majid and Mirhoseini, Leilaassadat and Sedehi, Morteza (2018) Serum concentration of hs-CRP in obese individuals with and without metabolic syndrome and its association with parameters of metabolic syndrome. JOURNAL OF RENAL INJURY PREVENTION, 7 (4).

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Abstract

Introduction: Serum level of high sensitivity C-reactive protein (hs-CRP), as an inflammatory marker, can play a role in development of metabolic syndrome in obese individuals. Objectives: This study aimed to determine serum concentration of hs-CRP in obese patients with metabolic syndrome and determine the association of this factor with factors involved in the progression of metabolic syndrome. Patients and Methods: In this study, samples were selected by convenient method from obese patients, admitted to Kashani and Hajar hospitals (Shahrekord, Iran). First, based on NCEP-ATPIII-defined metabolic syndrome, parameters of metabolic syndrome and serum levels of vitamin D were measured and a questionnaire containing demographics was completed for each participant. Accordingly, the samples (n=192) were divided into two identical groups; obese individuals without metabolic syndrome (controls) and obese individuals with metabolic syndrome (case group). Hs-CRP levels were measured in both groups. Results: Serum level of hs-CRP in the case group was 17.58 +/- 1.40 mu g/mL and in the control group was 9.04 +/- 1.26 mu g/mL, which was significantly higher in the case group than the control group (P < 0.001). Serum concentration of hs-CRP in case and control subjects had a negative significant correlation with vitamin D (P < 0.001), however, serum level of hs-CRP had no significant association with high density lipoprotein cholesterol (HDL-C), triglyceride (TG), fasting blood sugar (FBS), abdominal circumference, body mass index (BMI), and height (P > 0.05). Conclusion: Hs-CRP can be used for prognosis and early detection of patients at risk of metabolic syndrome.

Item Type: Article
Uncontrolled Keywords: Metabolic syndrome, Inflammatory markers, Metabolic parameters, Vitamin D
Subjects: WD Nutrition Disease and metabolic diseases
QU Biochemistry
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 11 Nov 2018 07:32
Last Modified: 20 Apr 2019 10:16
URI: http://eprints.skums.ac.ir/id/eprint/7341

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