In vitro evaluation of human endometrial stem cell-derived osteoblast-like cells’ behavior on gelatin/collagen/bioglass nanofibers’ scaffolds

Sharifi, Esmaeel. and Ebrahimi-Barough, Somayeh. and Panahi, Maryam. and Azami, Mahmoud. and Ai, Arman. and Barabadi, Zahra. and Kajbafzadeh, Abdol-Mohammad. and Ai, Jafar. (2016) In vitro evaluation of human endometrial stem cell-derived osteoblast-like cells’ behavior on gelatin/collagen/bioglass nanofibers’ scaffolds. Journal of Biomedical Materials Research - Part A, 104 (9). pp. 2210-2219.

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Abstract

New biomimetic nanocomposite scaffold was prepared by the combination of nanofibrilar bioglass containing copper ion as the inorganic phase and gelatin/collagen as the organic phase of bone tissue. In this study for fabrication of the scaffold, freeze drying and electrospinning methods were used, and genipin was used as the cross-linking agent for increasing the mechanical properties of the scaffold. The growth and viability of human endometrial stem cell-derived osteoblast-like cells were investigated on this biomimetic scaffold. Cellular biocompatibility assays illustrated that this scaffold has more viabilities and osteoblast growths in comparison with two-dimensional culture. Copper ion increased growth of the osteoblasts on nanocomposite scaffold containing nanofibrous bioglass. Thus, the results obtained from this study indicate that the prepared scaffold is suitable for osteoblast growth and attachment; thus, potentially, this nanocomposite scaffold is an appropriate scaffold for bone tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2210–2219, 2016.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: biomimetic, endometrial stem cells, nanocomposite, nanofibrilar bioglass, osteoblast cells
Subjects: QT physiology
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 04 Jul 2017 04:04
Last Modified: 13 Feb 2018 10:48
URI: http://eprints.skums.ac.ir/id/eprint/726

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