Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

Khosravian, Pegah and Khoobi, Mehdi and Shafiee Ardestani, Mehdi and Daryasari, Mohammad Porgham and Hassanzadeh, Malihe and Ghasemi-Dehkordi, Payam and Amanlou, Massoud and Akbari Javar, Hamid (2018) Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System. LETTERS IN DRUG DESIGN & DISCOVERY, 15 (7).

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Abstract

Methods: A large pore amine functionalized MSN (MSNs-NH2) is described here to facilitate delivery of clarithromycin (CLM) as an antibacterial drug and enhance the efficacy against Gram positive and Gram negative bacterial samples. Prepared particles were characterized by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), nitrogen adsorption/desorption isotherms, Fourier Transform Infrared (FT-IR) spectroscopy and X-ray Diffraction (XRD) spectroscopy. The antimicrobial activity was evaluated by agar well diffusion and broth dilution methods. Therefore, the biodistribution of FITC-MSNs was investigated by measure the NIR intensity fluorescent of fluorescent images from whole animal and dissected organs of NMRI mice. Results: The results showed that the CLM loaded MSNs-NH2 (CLM/MSNs-NH2) were successfully prepared having good payload and pH-sensitive drug release kinetics. The antimicrobial investigation against Staphylococcus aureus and Escherichia coli was showed better performance of antimicrobial activity of these nanoparticles. In vivo and ex vivo fluorescent imaging investigation on NMRI mice were shown that FITC-MSNs-NH2 accumulated in the liver and kidney and notably in lung tissue. Conclusion: The CLM/MSNs-NH2 exhibited higher antimicrobial activity and enhanced the possibility of microbial infection therapy especially at respiratory infections

Item Type: Article
Uncontrolled Keywords: Drug delivery, mesoporous silica nanoparticle, clarithromycin, antimicrobial activity, TEM, SEM
Subjects: WI Digestive System
QW Microbiology and Immunology
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 23 Sep 2018 09:25
Last Modified: 20 Apr 2019 07:39
URI: http://eprints.skums.ac.ir/id/eprint/7259

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