Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion

Torki, Akram and Khalaji-Pirbalouty, Valiallah and Lorigooini, Zahra and Rafieian-Kopaei, Mahmoud and Sadeghimanesh, Arezo and Rabiei, Zahra (2018) Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion. BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 54 (1).

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Abstract

Stroke is the third leading cause of mortality and disability in industrial countries. Treatment with herbs with antioxidant properties has been reported to be an alternative to the conventional treatments. This study was conducted to investigate the effect of Anchusa italica extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in the rat. To do so, 50 rats were randomly assigned to five groups; control, sham, ischemia, and 50 or 100 mg/kg of Anchusa italica treated animals. Ischemia was induced by occlusion of carotid artery for 30 minutes. Afterward, behavioral tests and biochemical analyses were conducted. Induction of ischemia/reperfusion caused a decline in learning and passive avoidance memory in rats. Moreover, Anchusa italica caused an increase in learning and improved the passive avoidance memory. Induction of ischemia/reperfusion caused a decrease in the antioxidant capacity of the brain and serum as well as an increase in the malondialdehyde of the brain and serum. Anchusa italica led to an increase in the antioxidant capacity of the brain and serum and decrease in the malondialdehyde of the brain and serum. Overall, because of its protective effects on spatial memory, passive avoidance learning, antioxidant capacity, and lipid peroxidation during ischemia/reperfusion, Anchusa italica might be beneficial in ischemic patients.

Item Type: Article
Uncontrolled Keywords: OXIDATIVE STRESS, ANTIOXIDANT ACTIVITY, MYOCARDIAL-ISCHEMIA, LIPID-PEROXIDATION, RAT HIPPOCAMPUS, BRAIN ISCHEMIA, CARDIAC-ARREST, HEART-DISEASE, FREE-RADICALS, ESSENTIAL OIL
Subjects: WH Hemic and Lymphatic System
WN Radiology . Diagnostic Imaging
QV pharmacology
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 23 Sep 2018 07:48
Last Modified: 23 Apr 2019 08:12
URI: http://eprints.skums.ac.ir/id/eprint/7255

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