Antidepressant effects of oleuropein in male mice by forced swim test and tail suspension test

Rabiei, Zahra. and Jahanbazi, Saeid. and Alibabaei, Zahra. and Rafieian-Kopaei, Mahmoud. (2018) Antidepressant effects of oleuropein in male mice by forced swim test and tail suspension test. WORLD FAMILY MEDICINE, 16 (4).

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Abstract

Abstract Objectives: With increasing prevalence of depression in communities and public concern regarding the side effects of synthetic drugs, special attention has recently been paid to identifying natural compounds with antidepressant effects. Oleuropein is an antioxidant polyphenol that is present in the leaves and fruits of different variants of olive. The aim of the present study was to investigate the antidepressant effects of oleuropein in mice by forced swim test (FST) and tail suspension test (TST). Methods: In this experimental study, 50 mice were randomly divided into 5 groups of 10. Group 1 received normal saline; group 2 intraperitoneally received reserpine at 5 mg/kg 18 hours before behavioral testing; group 3, in addition to reserpine, intraperitoneally received oleuropein at 10 mg/kg 15 minutes before behavioral testing; group 4, in addition to reserpine, received fluoxetine at 20 mg/kg; and group 5 received oleuropein at 10 mg/kg for 3 days and then reserpine 18 hours before behavioral testing. Behavioral tests were FST and TST. Finally, the antioxidant capacity and malondialdehyde (MDA) and nitric oxide (NO) levels in the serum and brain of the mice were measured. Results: Reserpine significantly increased the duration of immobility in FST and TST and significantly decreased serum and brain antioxidant capacity, significantly increased MDA levels in the brain and serum, and significantly increased serum NO level (P < 0.05). Oleuropein treatment for 3 days caused a significant decrease of immobility in FST, a significant increase in brain and serum antioxidant capacity, and a significant decrease of brain and serum MDA and NO levels (P < 0.05). Conclusion: Oleuropein was found to exhibit significant antidepressant effects in mice, probably due to its antioxidant activity.

Item Type: Article
Uncontrolled Keywords: Oleuropein; depression; reserpine
Subjects: WM Psychiatry
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 20 Sep 2018 06:01
Last Modified: 20 Sep 2018 06:01
URI: http://eprints.skums.ac.ir/id/eprint/7218

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