The effect of opioid use on pulmonary function test in advanced COPD patients

Koohi Habibi Dehkordi, Parinaz and Ayat, Sayed Mahdi and Rouhi Boroujeni, Hamid and Sohrabpour, Hamid and Fadaei, Abbas (2018) The effect of opioid use on pulmonary function test in advanced COPD patients. WORLD FAMILY MEDICINE.

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Abstract

Background: Opium has previously been shown to increase exercise endurance and decrease breathlessness in patients with chronic obstructive pulmonary disease, but controversy in this issue persists, therefore the role of opium in the management of patients with advanced COPD remains undefined. Method: In order to compare the effects of opium on pulmonary function, we studied two groups of patients with COPD who were attending the chest clinic of Labaffinejad hospital. Group A-consisted of COPD patients with history of smoking alone and group B-patients who consumed opium in addition to cigarette smoking. Patients were matched for their age, and packs/year cigarette smoking habit. Individuals with history of heart disease or occupational lung disease and those with severe COPD who needed hospitalization during 6 months prior to the study were excluded. A complete history and physical examination was done and patients' chest X-ray was taken. For each patient pulmonary function was evaluated by spirometry using Fukuda, Spirometric FVC, FEV 1, FEV 1 / FVC and predicted value for each parameter was recorded, and results were compared between the two groups of patients. Statistical analysis was done by using Kolmogorov - Smirnov test and student t-test. Results: Results shows that there is significant difference (p = 0) between the two groups for FVC and FEVI. We concluded that opium may have a beneficial effect in improving lung function in patients with severe COPD.

Item Type: Article
Uncontrolled Keywords: opioid use, pulmonary function test, COPD patients
Subjects: W General medicine- Health professions
WF Respiratory System
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 18 Sep 2018 06:56
Last Modified: 20 Apr 2019 07:45
URI: http://eprints.skums.ac.ir/id/eprint/7208

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