Uncovering the link between reproductive factors and multiple sclerosis: A case-control study on Iranian females

Salehi, Fatemeh and AbdNedjatollahpour, Ibrahim and Nedjat, Saharnaz and Sahraian, Mohammad Ali and Memari, Amir-Hossein and Rahnama, Maryam and Mansournia, Mohammad Ali (2018) Uncovering the link between reproductive factors and multiple sclerosis: A case-control study on Iranian females. Mult Scler Relat Disord.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/29414292


BACKGROUND: Increase of MS prevalence in females compared to males, especially in reproductive age, highlights the important role of reproductive factors in MS pathology. OBJECTIVES: We examined the association between females' reproductive age-related factors and MS risk. METHODS: A case-control study including 399 cases and 541 controls was carried out. The adjusted associations between MS risk and reproductive variables including age at menarche, oral contraceptive pills (OCPs) use history, OCP usage duration and age at first use, history of assisted reproductive technologies (ARTs) use, parity history, age at first childbirth and the number of parities, abortion and exclusive breast feeding > 2 months were assessed. RESULTS: We found protective relationships between MS and older age at menarche (OR = 0.90 {95% CI = 0.82-0.98}), ART use history (OR = 0.45 {95% CI = 0.21-0.99}), older maternal age at first childbirth (OR = 0.94{95% CI = 0.89 - 0.99}) and higher number of parities(OR = 0.61 {95% CI = 0.49 - 0.75), whereas using OCPs was associated with higher risk of developing MS (OR = 1.80 {95% CI = 1.35-2.41}). CONCLUSIONS: Links were noted between a number of reproductive factors and risk of MS. Copyright © 2018 Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Females, Multiple sclerosis, Pregnancy, Reproductive
Subjects: WE Musculoskeletal system
WP Gynecology
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 17 Sep 2018 06:10
Last Modified: 23 Apr 2019 05:14
URI: http://eprints.skums.ac.ir/id/eprint/7190

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