Protective and anti-inflammatory effects of hydroalcoholic leaf extract of Origanum vulgare on oxidative stress, TNF-α gene expression and liver histological changes in paraquat-induced hepatotoxicity in rats

Sharifi-Rigi, Ali and Heidarian, Esfandiar and Amini, Sayed Asadollah (2018) Protective and anti-inflammatory effects of hydroalcoholic leaf extract of Origanum vulgare on oxidative stress, TNF-α gene expression and liver histological changes in paraquat-induced hepatotoxicity in rats. Arch Physiol Biochem.

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Abstract

CONTEXT: Toxicity with paraquat can lead to serious damages to the liver. OBJECTIVE: The study investigates the protective effects of Origanum vulgare leaf extract against paraquat liver damage. MATERIAL AND METHODS: Rats were divided into six groups. Group 1, the control group; group 2, rats that received paraquat only; group 3, rats that received paraquat plus silymarin; and groups 4, 5, and 6 were treated with paraquat and O. vulgare leaf extract. Then, the serum and tissue parameters of the oxidative stress were examined. RESULTS: In group 2, paraquat caused a remarkable increase in the level of serum ALT, AST, ALP, lipid profiles, and liver TNF-α gene expression compared to group 1. The groups which received O. vulgare leaf extract exhibited significant ameliorations in abnormalities of paraquat-induced liver damage and serum biochemical parameters. CONCLUSION: O. vulgare leaf extract has inhibitory effects on paraquat-induced liver damage due to its antioxidant properties.

Item Type: Article
Uncontrolled Keywords: Hepatotoxicity, Origanum vulgare, histological changes, oxidative stress, paraquat
Subjects: QV pharmacology
Divisions: Reserach Vice-Chancellar Department > student research center
Depositing User: Unnamed user with email nazari@skums.ac.ir
Date Deposited: 17 Sep 2018 05:22
Last Modified: 17 Sep 2018 05:22
URI: http://eprints.skums.ac.ir/id/eprint/7189

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