Wound Healing Effects of Quercus Brantii and Pelargonium Graveolens Extracts in Male Wistar Rats

Lavasanijou, Mohammad Reza. and Sohrabi, Hamid Reza. and Karimi, Mehrdad. and Ashjazade, Mohammad Ali. and Salajeghe, Mohammad. and Farzineejadizadeh, Hossein. and Parsaei, Pouya. and Elmamooz, Ali. (2016) Wound Healing Effects of Quercus Brantii and Pelargonium Graveolens Extracts in Male Wistar Rats. Wounds, 28 (10). pp. 369-375.

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Abstract

Introduction. Wound healing comprises a complex pathophysiological process. Recent studies suggest plants play a major role as medications in wound healing. Quercus brantii and Pelargonium graveolens are 2 herbs used in Iran as a traditional remedy in speeding up the wound healing process. Materials and Methods. Forty male Wistar rats were divided into 4 groups of 10. Two distinct groups were reserved for the 2 herb extracts and 2 groups were allocated for positive and negative controls. The animals were anesthetized with ketamine and xylazine. After shaving their dorsal skin, a circular excision with an area approximation of 150 mm2 and 2 mm deep was created. Each rat received an application of 200 mg/kg/day of its allocated treatment. On days 3, 6, 9, 12, 15, 18, and 21, the wound areas were traced and photographed. On days 6, 12, and 18, biopsies were taken from the active peripheries. The data were collected and analyzed by statistical analysis software (SPSS for Windows Version 6, IBM, Armonk, NY). Results. The results were representative of the significant effects of Q. brantii extract on the enhancement of wound contraction velocity in comparison to nitrofurazone (on day 12, P = 0.001). According to histopathological assessments, healing in group A was significantly faster than the 3 other groups, even the positive control group (P < 0.01). Lesser inflammatory cells and fibrins in addition to more reepithelialization in group A in comparison to even positive control group, led to the potential of Q. brantii in treating wounds. Conclusion. The primary faster healing of P. graveolens plus the overall advantage of Q. brantii over nitrofurazone were confirmatory evidences of the traditional use of these herbs in the wound healing process.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Pelargonium graveolens, plant-based healing, Quercus brantii, wound healing
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Surgery
Depositing User: zahra bagheri .
Date Deposited: 03 Jul 2017 08:55
Last Modified: 15 Apr 2018 04:09
URI: http://eprints.skums.ac.ir/id/eprint/717

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