Select item 30102123 11. Differential expression of CCL18 in moderate/severe and mild persistent allergic rhinitis and its correlation with disease parameters

Pirayesh, A and Ferdosi, S and Shirzad, H and Amani, S and Bahadivand Chegini, H and Bagheri, N and Sadeghian, L and Torkamand, F (2018) Select item 30102123 11. Differential expression of CCL18 in moderate/severe and mild persistent allergic rhinitis and its correlation with disease parameters. J Immunoassay Immunochem.

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Abstract

BACKGROUND AND AIMS: This study aimed to assess the level of the expression of CCL-18 on nasal inferior turbinate mucosa in patients with mild (M) and moderate-to-severe (M/S) persistent allergic rhinitis (PAR). METHODS: The participants in this case-controlled study were divided into three groups: patients with M/S PAR, patients with M PAR, and the healthy control group. Biopsies of nasal inferior turbinate mucosa were obtained from the participants. Expression of CCL-18 mRNA was evaluated by real-time PCR. The serum levels of CCL-18 were determined by ELISA. Total serum IgE levels and specific serum IgE levels were measured. The clinical manifestations were assessed using the total nasal syndrome score (TNSS). RESULTS: Gene expression and the serum level of CCL-18 in patients with M/S PAR increased significantly compared to the control group and patients with M PAR. The serum level of CCL-18 was found to correlate with TNSS in patients with M/S PAR. There was a statistical correlation between the serum level of CCL-18 and the total serum IgE in the treatment groups. CONCLUSION: The results of the study indicate that there could be a relationship between the expression of CCL-18 in nasal turbinate mucosa and the severity of allergic rhinitis.

Item Type: Article
Uncontrolled Keywords: CCL-18, ELISA, disease severity, real-time PCR
Subjects: WV Otolaryngology
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Otolaryngology
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 12 Sep 2018 07:40
Last Modified: 12 Sep 2018 07:40
URI: http://eprints.skums.ac.ir/id/eprint/7138

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