Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review

Nazarian-Samani, Zeinab and D. E. Sewell, Robert and Lorigooini, Zahra and Rafieian-Kopaei, Mahmoud (2018) Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review. PHARMACOLOGIC TREATMENT OF TYPE 2 DIABETES (HE LEBOVITZ AND G BAHTIYAR, SECTION EDITORS).

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Abstract

Purpose of Review This systematic review describes evidence concerning medicinal plants that, in addition to exerting hypo- glycemic effects, decrease accompanying complications such as nephropathy, neuropathy, retinopathy, hypertension, and/or hyperlipidemia among individuals with diabetes mellitus (DM). Recent Findings Studies on the antidiabetic mechanisms of medicinal plants have shown that most of them produce hypogly- cemic activity by stimulating insulin secretion, augmenting peroxisome proliferator-activated receptors (PPARs), inhibiting α- amylase or α -glucosidase, glucagon-like peptide-1 (GLP-1) secretion, advanced glycation end product (AGE) formation, free radical scavenging plus antioxidant activity (against reactive oxygen or nitrogen species (ROS/RNS)), up-regulating or elevating translocation of glucose transporter type 4 (GLUT-4), and preventing development of insulin resistance. Summary Not only are medicinal plants effective in DM, but many of them also possess a variety of effects on other disease states, including the complications of DM. Such plants may be appropriate a lternatives or adjuncts to availa ble antidiabetic medications

Item Type: Article
Uncontrolled Keywords: Diabetes mellitus, Medicinal plants, Nephropathy, Neuropathy
Subjects: WD Nutrition Disease and metabolic diseases
WK Endocrine System
QU Biochemistry
QV pharmacology
Divisions: Faculty of Medicine
Depositing User: Unnamed user with email zamani.m@skums.ac.ir
Date Deposited: 11 Sep 2018 07:05
Last Modified: 11 Sep 2018 07:05
URI: http://eprints.skums.ac.ir/id/eprint/7112

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