Evaluation of spinacetin 7-O-β-D-glucopyranoside in the induction of apoptosis in breast cancer cell line MCF-7

Aghaei, Mahmoud. and Ghanadian, Mostafa. and Fallah, Moslem. and Solimani Dehkordi, Ebrahim. (2018) Evaluation of spinacetin 7-O-β-D-glucopyranoside in the induction of apoptosis in breast cancer cell line MCF-7. J Shahrekord Univ Med Sci., 20 (4).

Full text not available from this repository.

Abstract

Background and aims: This study was aimed to evaluate the effect of spinacetin 7-O-β-D-glucopyranoside, a flanovid compound separated from Centurea shmidi against MCF-7 breast cancer cell line and its effect on apoptosis induction. Methods: In this study, the inhibition rate of cell growth and induction of apoptosis in MCF-7 cell culture cells after treatment with different concentrations of spinostine glycoside was studied by MTT and flow cytometry. Results: According to the results of MTT test, after 48 hours treatment with spinostin-7-O- β-D-glucoside, a significant inhibition in cell proliferation was observed compared to the control group (P <0.05). The results of the study of apoptosis in the flow cytometry assay showed that the derived flavonoid increased significantly the apoptosis in MCF-7 breast cancer cell line (P<0.05). Conclusion: The derived flavonoid of spinacetin-7-O-β-D-glucopyranoside significantly inhibited MCF-7 proliferation and induced apoptosis. So, it could be suggested as a compound for breast cancer therapy.

Item Type: Article
Uncontrolled Keywords: Flavonoids, Apoptosis, Breast cancer, Cell cytotoxicities.
Subjects: QU Biochemistry
QZ pathology-Neoplasms
QV pharmacology
Divisions: Reserach Vice-Chancellar Department > Journal of Shahrekord University of Medical Sciences
Depositing User: zahra bagheri .
Date Deposited: 09 Sep 2018 11:42
Last Modified: 09 Sep 2018 11:42
URI: http://eprints.skums.ac.ir/id/eprint/7066

Actions (login required)

View Item View Item