Alteration in CD8+T cell subsets in enterovirus-infected patients: An alarming factor for type 1 diabetes mellitus

Zargari Samani, Omid. and Mahmoodnia, Lila. and Izad, Maryam. and shirzad, Hedayatollah. and Jamshidian, Azam. and Ghatreh samani, Mahdi. and Kheiri, Soleiman. and Sadeghian, Ladan. and Soltani, Amin. and Sarmadi, Akram. (2018) Alteration in CD8+T cell subsets in enterovirus-infected patients: An alarming factor for type 1 diabetes mellitus. Kaohsiung Journal of Medical Sciences.

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Abstract

Type 1 diabetes is a multi-factorial disease that can develop due to the combination of genetic and environmental factors. Viruses, particularly enteroviruses, are major environmental candidates in the pathogenesis of type 1 diabetes, even though the mechanisms of pathogenicity of these viruses and their effects on the immune system have not been understood very well yet. Previous studies show that any imbalance in the population of different lymphocyte subsets could develop autoimmune diseases. Our theory is that enteroviral infection causes an impairment in the distribution of lymphocyte subtypes and consequently results in the diabetes onset in some individuals. Therefore, in this project, we evaluated the distribution of T CD8+ lymphocytes and their subsets in type 1 diabetes patients. This study was conducted to investigate the relationship between enteroviral infection and type 1 diabetes mellitus in an Iranian population, and suggestion a predicting approach for susceptible subjects. © 2018

Item Type: Article
Uncontrolled Keywords: Type 1 diabetes mellitus;Enterovirus;CD8þT;Flow cytometry;GAD65
Subjects: WD Nutrition Disease and metabolic diseases
QW Microbiology and Immunology
Divisions: Faculty of Health > Department of Epidemiology
Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: Users 1 not found.
Date Deposited: 29 Aug 2018 08:38
Last Modified: 29 Aug 2018 08:38
URI: http://eprints.skums.ac.ir/id/eprint/7050

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