Efficacy of intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial

Eftekhar, M. and Miraj, S. and Mojtahedi, M.F. and Neghab, N. (2016) Efficacy of intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial. International Journal of Reproductive BioMedicine, 14 (11). pp. 687-690.

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Abstract

Background: Although pregnancy rate in in vitro fertilization-embryo transfer (IVF-ET) cycles has been increased over the preceding years, but the majority of IVF-ET cycles still fail. Granulocyte colony stimulating factor (GCSF) is a glycoprotein that stimulates cytokine growth factor and induces immune system which may improve pregnancy rate in women with history of implantation failure. Objective: The aim of this study was to evaluate GCSF ability to improve pregnancy rate in women with history of implantation failure Materials and Methods: 0.5 ml (300 μg/ml) GCSF was infused intrauterine in intervention group. Pregnancy outcomes were assessed based on clinical pregnancy. Results: The mean age of participants was 31.95±4.71 years old. There were no significant differences between demographic characteristics in two groups (p>0.05). The pregnancy outcome in GCSF group was improved significantly (p=0.043). Conclusion: GCSF can improve pregnancy outcome in patients with history of implantation failure

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: GCSF, In vitro fertilization, Pregnancy rate
Subjects: WP Gynecology
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Obstetrics and Gynecology
Depositing User: zahra bagheri .
Date Deposited: 03 Jul 2017 04:17
Last Modified: 03 Jul 2017 04:17
URI: http://eprints.skums.ac.ir/id/eprint/699

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