Effects of Thymus daenensis on inflammatory factors and liver toxicity induced by thioacetamide in rats

Soosani, Banafsheh. and Sazegar, Hossein. (2018) Effects of Thymus daenensis on inflammatory factors and liver toxicity induced by thioacetamide in rats. Journal of Herbmed Pharmacology., 7 (1).

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Abstract

Introduction: Thioacetamide (TAA) intoxication is underlying acute liver damage, inflammation, and tissue necrosis. The aim of this study was to evaluate of Thymus daenensis extract effect on acute liver disease induced by the thioacetamide and its effects on the tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) cytokines. Methods: In an experimental study, 36 male Wistar rats were divided into 6 groups of 6 each. The amount of 0.03-g thioacetamide dissolved in 1 mL of distilled water was injected intraperitoneally to all mice groups except the control group for 3 weeks, twice a week. The negative control group received only thioacetamide and the other groups received 8 mg/kg silibinin by gavage, other than to thioacetamide. The experimental groups, after injection of thioacetamide were treated with 5, 10 or 20 mg/kg extract of T. daenensis for 2 weeks. Peripheral blood samples were taken from the rats’ hearts after general anesthesia. Then, TNF-α and IL-6 cytokines levels were measured by Elisa kits. Pathology evaluation was also examined on liver. Results: TNF-α and IL-6 levels decreased in the groups treated with 5 mg/mL (respectively, P=0.001, P=0.05), 10 mg/mL (P<0.001, P<0.001, respectively) and 20 mg/mL (P<0.001, P<0.001) extracts compared to thioacetamide group. Histopathological studies indicated that liver lesions were improved in mice treated with T. daenensis extract compared with thioacetamide group. Conclusion: Thymus daenensis extract has anti-inflammatory and protective effects on liver toxicity induced by thioacetamide. Hence, it might be used for this purpose or for similar toxicities

Item Type: Article
Uncontrolled Keywords: Thioacetamide,Medicinal plants,Thyme daenensis TNF cytokines IL-6 cytokine
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: zahra bagheri .
Date Deposited: 14 Aug 2018 06:56
Last Modified: 14 Aug 2018 06:56
URI: http://eprints.skums.ac.ir/id/eprint/6988

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