Portulaca oleracea seeds extract does not prevent dexamethasone-induced hypertension in rats

Safaeian, Leila. and Baniahmad, Bahar. and Esfandiari, Zahra. and Alavi, Sayed Ali. (2018) Portulaca oleracea seeds extract does not prevent dexamethasone-induced hypertension in rats. Journal of Herbmed Pharmacology., 7 (1).


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Introduction: Portulaca oleracea is used as a nutritional and medicinal plant. The aim of this study was to assess the effect of hydroalcoholic extract of P. oleracea seeds in dexamethasone -induced hypertension in rats. Methods: For induction of hypertension, dexamethasone (30 µg/kg/d, subcutaneously) was administered for 14 days. Animals received P. oleracea extract as a pretreatment at various doses of 100, 200 and 400 mg/kg/d orally from 4 days before dexamethasone administration and during the test period. Systolic blood pressure (SBP) and heart rate were measured using tailcuff method. The weight of thymus gland was estimated as a marker of glucocorticoid activity. Results: Dexamethasone injection significantly increased SBP (P < 0.001) while decreased the body and thymus weights (P < 0.05 and P < 0.001, respectively). Oral administration of P. oleracea could not prevent rising in SBP and decreasing in thymus weight. It also increased heart rate in hypertensive rats at the dose of 400 mg/kg/d (P < 0.05). Conclusion: The results of this study revealed that hydroalcoholic extract of P. oleracea seeds aggregates hypertension in dexamethasone-induced hypertensive rats. Hence, it should be used with caution in hypertensive patients receiving glucocorticoids.

Item Type: Article
Uncontrolled Keywords: Portulaca oleracea,Hypertension,Dexamethasone
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: Users 1 not found.
Date Deposited: 12 Aug 2018 06:01
Last Modified: 12 Aug 2018 06:01
URI: http://eprints.skums.ac.ir/id/eprint/6979

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