Effects of Zingiber officinale hydro-alcoholic extract on HMG-COA reductase level in the testis of streptozotocininduced diabetic rats

Moradi-Podeh, Bahman. and Kheirollah, Alireza. and Ahmmadpour, Fatemeh. and Lamuchi-Deli, Nasrin. and Payami, Seyede-Arefe. and Mohammadzadeh, Ghorban. (2018) Effects of Zingiber officinale hydro-alcoholic extract on HMG-COA reductase level in the testis of streptozotocininduced diabetic rats. Journal of Herbmed Pharmacology., 7 (2).

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Abstract

Introduction: Zingiber officinale Roscoe, commonly known as ginger, is used as a cooking spice and therapeutically for its antioxidant and androgenic activities. We investigated the effects of Z. officinale hydro-alcoholic extract on HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase level in the testis of streptozotocin (STZ)-induced diabetic rats. Methods: The current experimental study was performed on four groups of male Wistar rats one of them was kept as a healthy control, while the others were rendered diabetic via a single intraperitoneal injection of STZ (60 mg kg-1). One group was considered as diabetic control; while the others were given orally hydro-alcoholic extract (200 and 400 mg kg-1) for 56 consecutive days. Body weight, blood glucose and insulin concentrations were evaluated using standard methods. The HMG-COA reductase level was determined by western blot analysis. Results: Treatment with the extract resulted in a significant reduction of serum glucose concentration and HMG-COA reductase level in the rat’s testis compared to diabetic controls (P<0.01). A significant increase in body weight was observed in treated diabetic rats. Also, serum insulin was significantly increased in diabetic rats treated with 400 mg/kg of the extract compared to diabetic controls (P<0.05). Conclusion: Ginger has a potential influence on the regulation of cholesterol homeostasis by modulating of HMG-COA reductase level. The results provide scientific evidence to confirm the traditional use of Z. officinale in the treatment of diabetes mellitus.

Item Type: Article
Uncontrolled Keywords: Streptozotocin-induced diabetes,HMG-COA reductase,Zingiber officinale,Medicinal plant
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: Users 1 not found.
Date Deposited: 12 Aug 2018 04:33
Last Modified: 12 Aug 2018 04:33
URI: http://eprints.skums.ac.ir/id/eprint/6973

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