Preventive effects of Allium hirtifolium Boiss methanolic and aqueous extracts on renal injury induced by lead in rats

Hajian, Nafise. and Rezayatmand, Zahra. and Shahanipur, Kahin. (2018) Preventive effects of Allium hirtifolium Boiss methanolic and aqueous extracts on renal injury induced by lead in rats. Journal of Herbmed Pharmacology, 7 (3).

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Abstract

Introduction: In this study the kidney protective effects of methanolic and aqueous extracts of Allium hirtifolium Boiss (shallot) were evaluated on kidney toxicity induced by lead (Pb) in Wistar rats. Methods: Eighty adult female Wistar rats of 3–5 months of age and weighing 200–250 g were allocated randomly into 10 groups and treated for 15 and 30 days as follows: control group, Pb (10 mg/L), methanolic extract of shallot (12.5 mg/kg and 25 mg/kg), Pb plus methanolic extract of shallot (12.5 mg/kg and 25 mg/kg), aqueous extract of shallot (12.5 mg/kg and 25 mg/kg), Pb plus aqueous extract of shallot (12.5 mg/kg and 25 mg/kg). Serum concentrations of glucose as well as renal parameters were measured at 15 days and 30 days in the studied groups. Results: Analysis showed a significant reduction in the mean of urea in the methanolic extract group with a concentration of 12.5 mg/kg, compared to the lead group. Consumption of 25 mg/kg methanolic extract of shallot showed a significantly reduction of uric acid, creatinine and total protein in comparison with control group and lead group. Consumption of 25 mg/kg methanolic extract of shallot+lead was able to reduce the mean of urea uric acid, creatinine and total protein in comparison with lead group. Also, the results showed that methanolic extract of shallot+lead at a dose of 12.5 mg/kg could reduce the mean of urea uric acid, creatinine and total protein in comparison with lead group. There was no significant difference in the rest groups. Conclusion: The results of the study showed that shallot extract can dose dependently reduce the factors related to lead induced renal damages.

Item Type: Article
Uncontrolled Keywords: Hepatic enzymes,Renal,Lead acetate,Shallot
Subjects: WJ Urogenital System
QV pharmacology > QV 600 Toxicology
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: zahra bagheri .
Date Deposited: 06 Aug 2018 04:24
Last Modified: 06 Aug 2018 04:24
URI: http://eprints.skums.ac.ir/id/eprint/6960

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