Clinical relevance of Helicobacter pylori virulence factors in Iranian patients with gastrointestinal diseases

Bagheri, Nader. and Azadegan-Dehkordi, Fatemeh. and Rafieian-Kopaei, Mahmoud. and Rahimian, Ghorbanali. and Asadi-Samani, Majid. and shirzad, Hedayatollah. (2016) Clinical relevance of Helicobacter pylori virulence factors in Iranian patients with gastrointestinal diseases. Microbial Pathogenesis, 100. pp. 154-162.


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Helicobacter pylori (H. pylori) usually colonizes the gastric mucosa of more than 50% of the human population, causing an infection that may appear in early childhood and can persist for life. H. pylori is suggested as the main cause of peptic ulcer and chronic gastritis. It is also associated with gastric cancer. Its severity and symptoms depend on environmental factors, host susceptibility and bacterial components, which allow H. pylori to switch between commensalism and pathogenicity. H. pylori is genetically highly variable, and the variability which affects H. pylori virulence factors might be useful in identifying the strains with different degrees of pathogenicity. The geographic distribution of distinct H. pylori genotypes is largely unknown and should be established. The prevalence of more pathogenic genotypes in certain areas may have important epidemiological consequences. It also might be associated with the severity of H. pylori related diseases in such regions. Given that Iran is located in the Middle East and Asian populations have revealed high levels of gastric cancer, it is of clinical interest to clarify the potential of H. pylori virulence markers in predicting the associated clinical outcomes. In this review, clinical relevance of adhesion molecules and significant virulence factors of H. pylori in Iranian patients with gastrointestinal diseases are discussed in comparison to other countries.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Gastric cancer, Gastritis, Helicobacter pylori, Peptic ulcers, Virulence factors
Subjects: WI Digestive System
QU Biochemistry
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 03 Jul 2017 03:44
Last Modified: 30 Jan 2018 08:28

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