Diversity and ecotypic variation in the antioxidant and antigenotoxic effects of Thymus kotschyanus Boiss & Hohen

Afshari, Vahid. and Elahian, Fatemeh. and Ayari, Yasaman. and Yazdinezhad, Alireza. and Mirzaei, Seyed Abbas. (2016) Diversity and ecotypic variation in the antioxidant and antigenotoxic effects of Thymus kotschyanus Boiss & Hohen. Flavour and Fragrance Journal, 31 (6). pp. 429-437.


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Thymus species are amongst the most popular medicinal plants because of their biological effects and pharmacological properties, and they are widely used in folk medicine for many disorders. Fourteen ecotypic Thymus kotschyanus essential oils were isolated, and the biological functionalities of ecotypic oils were characterized in terms of free radical scavenging and antigenotoxic properties. The most abundant ecotypic oil constituents were thymol and carvacrol (27.2–75.6%). The oils produced scavenging capacity, bleaching inhibitory capacity, and COMET-inhibitory capacity values in a dose-dependent manner ranging from 0.15 to 4.79 mg/ml, 0.04 to 3.1 mg/ml and 0.03 to 5.00 mg/ml, respectively. The benefits of T. kotschyanus essential oils from different regions vary, and they represent an inexpensive source of natural substances that have the potential to be used as antioxidative and antigenotoxic agents. Although the impacts of the microenvironment, climate difference and agronomical condition on the medical benefits of the plant were complex and highly context dependent, some correlations among the biological effects, main essential constituents, and the geographical environment were predicted. Copyright © 2016 John Wiley & Sons, Ltd. Copyright

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: antigenotoxicity, antioxidant, essential oil, geographical variation, Thymus kotschyanus
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: Users 1 not found.
Date Deposited: 03 Jul 2017 03:40
Last Modified: 25 Feb 2018 06:52
URI: http://eprints.skums.ac.ir/id/eprint/695

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